| Description | GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM). |
| In vitro | 在对人类角质形成细胞的增殖单层培养进行GNF351（500 nM，48小时）处理后，明显降低了Ki67阳性细胞的百分比和细胞数量。 |
| Target activity | AhR:62 nM (IC50) |
| molecular weight | 411.5 |
| Molecular formula | C24H25N7 |
| CAS | 1227634-69-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 124 mg/mL(301.34 mM) |
| References | 1. van den Bogaard EH,et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328. |