| Description | Glp-1(7-37) acetate is an intestinal insulin hormone that enhances glucose-induced insulin secretion. |
| In vivo | GLP-1(7-37)(0.5、5或50 pmol/min/kg)在2小时11-mM高血糖夹持过程的第二小时注入，能够与剂量相关地增强由葡萄糖刺激所引起的血浆胰岛素浓度上升，并在大鼠中增加葡萄糖输注速率[2]。从第1小时至第7小时持续注入GLP-1(7-37)(5 pmol/min/kg)，与注入载体的大鼠相比，在维持11 mM葡萄糖浓度的大鼠中，可产生持续增加的血浆胰岛素浓度[2]。 |
| Synonyms | GLP-1(7-37) acetate |
| molecular weight | 3355.67 |
| Molecular formula | C151H228N40O47 |
| CAS | 1450806-98-0 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 12.5 mg/mL (3.73 mM), Sonication is recommended. H2O: Soluble |
| References | 1. Sarrauste de Menthiere, C. et al. Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production. European journal of medicinal chemistry 39, 473-480, doi:10.1016/j.ejmech.2004.02.002 (2004). 2. Hargrove DM, et al. Glucose-dependent action of glucagon-like peptide-1 (7-37) in vivo during short- or long-term administration. Metabolism. 1995 Sep;44(9):1231-7. |