| Description | Cyclo(Pro-Ala) is a natural product. |
| In vitro | 为了从Streptomyces flavoretus 18522的代谢产物中寻找细胞周期抑制剂。方法与结果：通过使用ts FT210细胞，对Streptomyces flavoretus 18522的发酵液和菌丝体的氯仿提取物进行了活性导向分离。通过各种色谱方法分离化合物，并通过光谱方法阐明化合物结构。流式细胞术被用于评价分数和化合物的细胞周期抑制活性。得到六个环状二肽并识别为cyclo(Ala-Leu)(1), cyclo(Ala-Ile)(2), cyclo(Ala-Val)(3), cyclo(Phe-Leu)(4), Cyclo(Pro-Ala)(5) 和 cyclo(Phe-Val)(6)。结论：化合物1-6首次被报道为新的细胞周期抑制剂。 |
| molecular weight | 168.19 |
| Molecular formula | C8H12N2O2 |
| CAS | 65556-33-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 11 mg/mL (65.4 mM) |
| References | 1. Cyclic dipeptides as new cell cycle inhibitors produced by Streptomyces flavoretus Journal of Shenyang Pharmaceutical University, 2015(2):107 -10. |