| Description | Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells. |
| Target activity | α1β1γ2 GABAA receptor:17.23 μM(EC50), α1β2 GABAA receptor:9.63 μM(EC50), α1β3γ2 GABAA receptor:6.83 μM(EC50), α1β2γ2 GABAA receptor:6.3 μM(EC50) |
| Synonyms | 光甘草定, Q-100692, KB-289522, LS-176045 |
| molecular weight | 324.37 |
| Molecular formula | C20H20O4 |
| CAS | 59870-68-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 75 mg/mL (231.22 mM) Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble |
| References | 1. Yokota Tm , et al. Pigment Cell Res. 1998 Dec;11(6):355-61. 2. Yehuda I, et al. Mol Nutr Food Res. 2015 Jun;59(6):1041-52. 3. Hsieh MJ, et al. Br J Pharmacol. 2014 Jun;171(12):3037-50. 6. El-Ashmawy NE, et al. Downregulation of iNOS and elevation of cAMP mediate the anti-inflammatory effect of glabridin in rats with ulcerative colitis. Inflammopharmacology. 2018 Apr;26(2):551-559. |
| Citations | 1. Yan Y, Xia X, Fatima A, et al.Antibacterial Activity and Mechanisms of Plant Flavonoids against Gram-Negative Bacteria Based on the Antibacterial Statistical Model.Pharmaceuticals.2024, 17(3): 292. |