| Description | γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM. It is specifically designed for Alzheimer's disease research. Notably, γ-Secretase modulator 12 exhibits a favorable brain/plasma ratio (Kp, brain = 0.72) in mice [1]. |
| molecular weight | 397.47 |
| Molecular formula | C25H23N3O2 |
| CAS | 2204249-82-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |