| Description | Galnon is a galanin receptor agonist, improves intrinsic cortical bone tissue properties |
| In vivo | Galnon已被鉴定为能够抑制癫痫发作、减少进食行为、减轻阿片类化合物撤离的体征并减轻部分坐骨神经损伤后的热痛觉过敏反应[1]。作为GAL受体激动剂的Galnon，可能在OVX大鼠中增强破骨细胞的骨吸收。尽管Galnon减少了骨体积，但生物力学测试显示，经Galnon处理的动物的骨骼按单位面积计算机械上更为优越。总而言之，Galnon在刺激OVX大鼠模型中破骨活动的同时，同时提高了皮质骨的内在质量[2]。 |
| molecular weight | 678.82 |
| Molecular formula | C40H46N4O6 |
| CAS | 475115-35-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Sollenberg U , Bartfai T , Langel U . Galnon - A low-molecular weight ligand of the galanin receptors[J]. Neuropeptides, 2005, 39(3):161-163. 2. Mcgowan H W , Schuijers J A , Grills B L , et al. Galnon, a galanin receptor agonist, improves intrinsic cortical bone tissue properties but exacerbates bone loss in an ovariectomised rat model.[J]. Journal of Musculoskeletal & Neuronal Interactions, 2014, 14(2):162. |