| Description | BMS-193885 is a selective, brain-penetrant, and competitive antagonist of the neuropeptide Y1 receptor with a Ki of 3.3 nM, and an IC50 of 5.9 nM for hY1. |
| Target activity | Y1 (human):5.9 nM(ki), NPY1 receptor:（ki）3.3 nM |
| molecular weight | 590.71 |
| Molecular formula | C33H42N4O6 |
| CAS | 186185-03-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90 mg/mL (152.4 mM), Sonication is recommended. |
| References | 1. Antal-Zimanyi I, et al. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590(1-3):224-32. 2. Poindexter GS, et al. Dihydropyridine neuropeptide Y Y(1) receptor antagonists. Bioorg Med Chem Lett. 2002 Feb 11;12(3):379-82. |