| Description | FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibition of FTIDC for mGluR1 receptors is shown to be in noncompetitive manner and displays IC50 values of 5.8 and 3.1 nM for human and mouse mGluR1 expressed in CHO cells respectively. |
| Target activity | mGluR1(human):5.8 nM, mGluR1(mouse):3.1 nM |
| molecular weight | 358.41 |
| Molecular formula | C18H23FN6O |
| CAS | 873551-53-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 35.8 mg/mL (100 mM) |
| References | 1. Ito S, et al. Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist. Bioorg Med Chem. 2008 Nov 15;16(22):9817-29. |