| Description | Direct Blue 1 (Pontamine sky blue), a counterstain for background autofluorescence in immunofluorescence histochemistry, structurally resembles glutamate and operates as a potent, competitive VGLUT inhibitor, not impacting plasma membrane transporters. This compound stands out as the inaugural small molecule PrP ligand to inhibit Aβ binding. |
| Synonyms | Pontamine sky blue, 滂胺天蓝, Chicago Sky Blue 6B |
| molecular weight | 992.8 |
| Molecular formula | C34H24N6Na4O16S4 |
| CAS | 2610-05-1 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Slightly soluble |
| References | 1. Yu G, et al. Behav Pharmacol. 2013 Dec;24(8):653-8. |