| Description | Fosnetupitant chloride monohydrochloride (Pro-netupitant chloride monohydrochloride) is a selective NK1 antagonist exhibiting high affinity for the human NK1 receptor with a pK i value of 9.5, and a lower affinity for the NK3 receptor with a pK i of 6.1. It serves as a methylene phosphate prodrug of Netupitant [1]. |
| In vitro | Fosnetupitant chloride monohydrochloride 对 5-HT6 受体（pKi 约 5.2）和 L 型 Ca2+ 通道（pKi > 约 5.7）具有微摩尔级别的亲和力，且未与研究中的其他所有蛋白质发生结合[1]。 |
| In vivo | Fosnetupitant氯化单氢化物(i.v.)能够在数分钟内迅速转化成Netupitant [1]。 |
| Target activity | NK1 (human):9.5 (pKi), NK3 (human):6.1 (pKi) |
| Synonyms | Pronetupitant chloride monohydrochloride |
| molecular weight | 761.52 |
| Molecular formula | C31H37Cl2F6N4O5P |
| CAS | 1643757-72-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Fosnetupitant chloride monohydrochloride
CAS No.: 1643757-72-5
Fosnetupitant chloride monohydrochloride (Pro-netupitant chloride monohydrochloride) is a selective NK1 antagonist exhib
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