| Description | Eledoisin Related Peptide (Eledoisin RP) is a tachykinin receptor ligand. |
| In vivo | Substance P和eledoisin-related peptide对呼吸神经元和反射性神经元具有兴奋作用，但与谷氨酸诱导的效应相比，激活的起始更缓慢，持续时间更长。两者都能促进节律性和诱发性活动，效应的大小与喷射电流的大小成正比。研究显示，谷氨酸和Substance P（及其类似物eledoisin-related peptide）都能对呼吸神经元和反射性神经元的活动产生兴奋效应[1]。 |
| Synonyms | Eledoisin RP, Eledoisin-Related Peptide, Eledoisin Related Peptide(2TFA) |
| molecular weight | 706.94 |
| Molecular formula | C34H58N8O6S |
| CAS | 2990-43-4 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mM |
| References | 1. Severini C, et al. The tachykinin peptide family. Pharmacol Rev. 2002 Jun;54(2):285-322. 2. Guyenet P G , Aghajanian G K . Excitation of neurons in the nucleus locus coeruleus by substance P and related peptides[J]. Brain Research, 1977, 136(1):178-184. 3. Henry J L , Sessle B J . Effects of glutamate, substance P and eledoisin-related peptide on solitary tract neurones involved in respiration and respiratory reflexes[J]. Neuroscience, 1985, 14(3):863-873. |