| Description | FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1) |
| In vitro | FEN1-IN-4选择性抑制缺失Cdc4和Mre11a的结肠癌细胞增殖，这两种蛋白在结直肠癌中经常发生突变。FEN1还因其在LP-BER中的角色而成为潜在的化疗增敏靶点，这对于修复MMS（甲基甲磺酸盐）引起的烷基化损伤至关重要，其敲降或抑制可增加胶质母细胞瘤和结直肠癌细胞系对TMZ（替莫唑胺）的敏感性。 |
| Synonyms | FEN1 Inhibitor C2 |
| molecular weight | 232.24 |
| Molecular formula | C12H12N2O3 |
| CAS | 1995893-58-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (430.59 mM), Sonication is recommended. |
| References | 1. Jack C Exell, et al. Cellularly Active N-hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site. Nat Chem Biol. 2016 Oct;12(10):815-21. |