| Description | 5-A-RU hydrochloride (5-Amino-6-(D-ribitylamino)uracil hydrochloride) is an intermediate of bacterial riboflavin that activates mucosal-associated invariant T cells (MAIT).5-A-RU is used in the study of breast and prostate cancer. |
| In vitro | 5-A-RU hydrochloride（2 μM）可用于刺激人 MAIT 细胞和生产用于 MAIT 细胞鉴定的人和小鼠 MR1 四聚体[1]。 |
| In vivo | 当在体内注射前 5-A-RU hydrochloride (100 nM; i.p.; 18 hours)和 MeG 在外界混合时，iVα19 Cα−/−-Tg mice 体内的 MAIT 细胞被激活[2]。 |
| Synonyms | 5-Amino-6-(D-ribitylamino)uracil hydrochloride |
| molecular weight | 312.71 |
| Molecular formula | C9H17ClN4O6 |
| CAS | 134452-11-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 100 mg/mL (319.78 mM), Sonication and heating are recommended. |
| References | 1. Li K,et al. Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU). PLoS One. 2018 Feb 5;13(2):e0191837. 2. Soudais C,et al. In Vitro and In Vivo Analysis of the Gram-Negative Bacteria-Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells. J Immunol. 2015 May 15;194(10):4641-9. 3. Mak JY, et al. Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells. Nat Commun. 2017 Mar 8;8:14599. |