| Description | EUK-134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril. |
| In vitro | EUK 134展示了强大的过氧化氢酶和超氧化物歧化酶活性，能够保护人类成纤维细胞免受葡萄糖和葡萄糖氧化酶的细胞毒性伤害。[1]EUK 134 (20 μM) 能够预防Aβ诱导的体外小胶质细胞增殖。[2]在SK-N-MC细胞中，EUK134通过抑制MAPK通路减轻氧化应激，保护神经细胞免受H(2)O(2)的毒性伤害，并导致促凋亡基因p53和Bax的表达降低，同时增强抗凋亡Bcl-2基因的表达。[3]EUK 134在两个摩尔比1:1和5:1（化合物：蛋白）显著抑制淀粉样蛋白的形成。[4] |
| In vivo | 在中大脑动脉闭塞模型中，EUK 134（2.5 mg/kg）显著减小脑梗塞面积，并显著阻止梗塞进一步增大。[1] EUK-134 防止氧化应激，并减轻由全身给予系统性海因酸（KA）所诱导的大鼠脑损伤。[5] |
| Synonyms | EUK 134, 乙基双亚氨基甲基愈创木酚锰氯化物 |
| molecular weight | 416.74 |
| Molecular formula | C18H18ClMnN2O4 |
| CAS | 81065-76-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (24 mM), Sonication is recommended. H2O: 11 mg/mL (26.4 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Baker K, et al. J Pharmacol Exp Ther. 1998, 284(1), 215-221. 2. Jekabsone A, et al. J Neuroinflammation. 2006, 3, 24. 3. Mohammadi M, et al. Basic Clin Pharmacol Toxicol. 2011, 108(6), 378-384. 4. Bahramikia S, et al. Eur J Pharmacol. 2013, 707(1-3), 17-25. 5. Rong Y, et al. Proc Natl Acad Sci U S A. 1999, 96(17), 19897-19902. |