| Description | Etiprednol dicloacetate (BNP-166) is a corticosteroid with anti-inflammatory activity.Etiprednol dicloacetate inhibits the accumulation of eosinophils and can be used in the study of inflammatory airway diseases such as asthma and in the treatment of Crohn's disease. |
| In vitro | Etiprednol dicloacetate（1 nM-1 μM）抑制LPS诱导的人血中TNF-α产生。[1] |
| In vivo | Etiprednol dicloacetate（0-100 μg/kg；经鼻吸入）可减少经过致敏和挑战的大鼠肺部周细支气管的嗜酸性粒细胞浸润。[1] 同时，Etiprednol dicloacetate（0-20 mg/kg；口服；连续28天）在大鼠和狗中表现出良好的耐受性。[2] 此外，Etiprednol dicloacetate（0.1 μg/kg；经鼻吸入）能够抑制因抗原暴露引起的大鼠嗜酸性粒细胞积聚。[3] |
| Synonyms | BNP 166, BNP166, BNP-166 |
| molecular weight | 485.4 |
| Molecular formula | C24H30Cl2O6 |
| CAS | 199331-40-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (113.31 mM) |
| References | 1. Kurucz I, et al. Potency and specificity of the pharmacological action of a new, antiasthmatic, topically administered soft steroid, etiprednol dicloacetate (BNP-166). J Pharmacol Exp Ther. 2003;307(1):83-92. 2. Miklós A, et al. 28-day oral toxicity study with soft corticosteroid BNP-166 in rats and dogs, followed by a 14-day recovery period. Pharmazie. 2002;57(2):142-146. 3. Kurucz I, et al. Anti-inflammatory effect and soft properties of etiprednol dicloacetate (BNP-166), a new, anti-asthmatic steroid. Pharmazie. 2004;59(5):412-416. 4. Yang J, et al. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc Natl Acad Sci U S A. 2018;115(26):6792-6797. |