| Description | ER degrader 7 (Compound 35t) is a selective degrader of both ERα and ERβ, and possesses activity as a tubulin polymerization inhibitor. It exhibits potent cell viability inhibition, with IC50 values of 0.06 μM for MCF-7, 2.56 μM for T47D, 15.84 μM for MCF-10A, 1.59 μM for LCC2, 1.67 μM for T47D D538G, and 1.37 μM for T47D Y537S cells. Additionally, ER degrader 7 demonstrates efficacy in suppressing breast cancer tumor growth [1]. |
| molecular weight | 736.63 |
| Molecular formula | C33H31F4N3O5SSe |
| CAS | 2922929-63-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |