| Description | Antifungal agent 72 (Compound B8) demonstrates potent activity by inhibiting the efflux pump function and downregulating resistance-associated genes via disruption of the Pdr1-KIX interaction (K i : 11.7 μM). It exhibits efficacy against Fluconazole-resistant strains, evidenced by a MIC of 63 ng/mL, and displays synergistic effects when combined with Fluconazole. This compound is particularly useful for researching C. glabrata infections [1]. |
| molecular weight | 274.34 |
| Molecular formula | C13H14N4OS |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |