| Description | Epirizole (Mebron) shows antipyretic, analgesic, and anti-inflammatory activity and can be used in studies about chronic rheumatoid arthritis. |
| In vitro | 在Caco-2细胞中，Epirizole（1、10、100及1000 μM）提高了MDR1 mRNA表达水平[1]。 |
| Synonyms | DA 398, Mepirizole, DA398, Mebron, Methopyrimazole, Dalex, DA-398 |
| molecular weight | 234.25 |
| Molecular formula | C11H14N4O2 |
| CAS | 18694-40-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 27.5 mg/mL (117.4 mM) |
| References | 1. Kawashima Y, et al. Preparations of agglomerated crystals of polymorphic mixtures and a new complex of indomethacin-epirizole by the spherical crystallization technique. J Pharm Sci. 1985 Nov;74(11):1152-6. 2. Khomenko T, et al. STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration. Dig Dis Sci. 2014 Feb;59(2):297-306. 3. Gallo M, La Montagna G. [Controlled research on the use of epirizole in the therapy of rheumatoid arthritis]. Clin Ter. 1983 Sep 30;106(6):429-33. Italian. 4. Takara K, et al. Effects of nonsteroidal anti-inflammatory drugs on the expression and function of P-glycoprotein/MDR1 in Caco-2 cells. Drug Chem Toxicol. 2009;32(4):332-7. |