| Description | BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it. |
| In vitro | Treatment of HepG2 cells with BRD0418 for 6 hours resulted on average in 3.5-fold up-regulation of TRIB1 transcript levels, with half-maximal effect achieved at 2.3 μM concentration of the compound[1]. |
| Synonyms | BRD 0418, BRD-0418 |
| molecular weight | 488.57 |
| Molecular formula | C29H32N2O5 |
| CAS | 1565827-99-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (112.57 mM) |
| References | 1. Nagiec MM, et al. Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. PLoS One. 2015 Mar 26;10(3):e0120295. |