Enpp/Carbonic anhydrase-IN-1 Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase. Enpp/Carbonic anhydrase-IN-1 exhibits IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 µM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 exhibits selective antiproliferative activity for cancer cells.
In vitro	Enpp/Carbonic anhydrase-IN-1 (0-100 µM; ) inhibits cancer cells growth with IC50s of 0.32, 0.40, 0.40, 0.58, 0.87, 0.96 µM for K-562, RPMI-8226, HT-29, SR, COLO 205, SF-539 cells, respectively. Enpp/Carbonic anhydrase-IN-1 (0-2 µM) exhibits low cytotoxic against normal skin fibroblast cells (F180) and normal breast epithelial cells (HME1) with IC50s of > 50 μM. Enpp/Carbonic anhydrase-IN-1 (0.32 µM, 0.64 µM) induces apoptosis in a dose-dependent manner at K-562 cells[1].
Target activity	NPP3:3 µM, CA II:0.88 µM, CA IX:1.02 µM, NPP1:1.36 µM, NPP2:1.35 µM
molecular weight	411.51
Molecular formula	C23H25NO4S
CAS	2883495-35-8
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility	DMSO: 90.0 mg/mL (218.7 mM), Sonication and heating to 50℃ are recommended.
References	1. Afnan I.Shahin, et al. Design and synthesis of new adamantyl derivatives as promising antiproliferative agents. European Journal of Medicinal Chemistry, 2022.

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