| Description | Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor. |
| In vitro | 0.6 mg Brinzolamide眼悬液可以以剂量依赖的方式降低激光治疗青光眼手术后食蟹猴的眼内压.< 1 mg Brinzolamide眼悬液可以以剂量依赖的方式降低荷兰束带兔眼内压.1 mg/kg,10 mg/kg和30 mg/kg剂量 Brinzolamide可以分别使雄性CD-1小鼠的巴比妥睡眠时间延长57%,15%和35%.< 3%的Brinzolamide可以使原发性开角型青光眼病人或高眼压病人的平均眼内压下降百分比和平均眼内压下降值比安慰剂组明显增多.对于安静状态下的荷兰束带兔,2%的Brinzolamide可以增加其视神经乳头血流量并降低其眼内压. |
| Target activity | CA II:3.19 nM |
| Synonyms | 布林佐胺, AL-4862 |
| molecular weight | 383.51 |
| Molecular formula | C12H21N3O5S3 |
| CAS | 138890-62-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 60 mg/mL (156.45 mM), Sonication is recommended. |
| References | 1. DeSantis L, et al. Surv Ophthalmol, 2000, Suppl 2, S119-129. 2. Silver LH, et al. Surv Ophthalmol, 2000, 44 Suppl 2, S147-153. 3. Kaup M, et al. Br J Ophthalmol, 2004, 88(2), 257-262. 4. Barnes GE, et al. Surv Ophthalmol, 2000, 44 Suppl 2, S131-140. 5. Yamada M, et al. J Cereb Blood Flow Metab, 2000, 20(4), 709-717. |