| Description | Elomotecan (BN 80927 free base), a camptothecin analog from the homocamptothecin family (hCPT), serves as a potent inhibitor of topoisomerases I and II. It effectively reduces the proliferation of various tumor cells more significantly than other reference anticancer drugs targeting the same topoisomerases [1].This compound is unstable in powder form and other related salt forms are recommended. |
| In vitro | WEHI-539 induces noticeable PARP cleavage in Ovcar-4 (5 μM in Ovcar-4.) and Ovsaho (1 μM in Ovsaho) cells. WEHI-539 augments Carboplatin induced caspase 3/7 activity, PARP cleavage, and annexin V labeling.[2] |
| Synonyms | BN 80927 free base |
| molecular weight | 522.04 |
| Molecular formula | C29H32ClN3O4 |
| CAS | 220998-10-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |