| Description | AZD-5099 is a DNA gyrase modulator potentially for the treatment of bacterial infection. |
| Synonyms | AZD5099 |
| molecular weight | 548.44 |
| Molecular formula | C21H27Cl2N5O6S |
| CAS | 907543-25-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Bisacchi GS, Manchester JI. A New-Class Antibacterial-Almost. Lessons in Drug Discovery and Development: A Critical Analysis of More than 50 Years of Effort toward ATPase Inhibitors of DNA Gyrase and Topoisomerase IV. ACS Infect Dis. 2015 Jan 9;1(1):4-41. doi: 10.1021/id500013t. PubMed PMID: 27620144. 2. Basarab GS, Hill PJ, Garner CE, Hull K, Green O, Sherer BA, Dangel PB, Manchester JI, Bist S, Hauck S, Zhou F, Uria-Nickelsen M, Illingworth R, Alm R, Rooney M, Eakin AE. Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099). J Med Chem. 2014 Jul 24;57(14):6060-82. doi: 10.1021/jm500462x. PubMed PMID: 24959892. |