| Description | Elamipretide 2TFA (RX-31 2TFA) is a novel mitochondrion-targeted antioxidant. |
| In vivo | 使用elamipretide显著改善了LPS引起的学习和记忆障碍，在行为测试中表现出显著效果。值得注意的是，elamipretide不仅对抗线粒体功能失调和氧化应激提供了保护作用，还促进了脑源性神经营养因子（BDNF）信号传导的调节，包括重要突触信号蛋白的逆转和突触结构复杂性的增加[1]。 |
| Synonyms | MTP-131 2TFA, RX-31 2TFA, SS-31, MTP-131, SS-31 2TFA, Bendavia |
| molecular weight | 867.84 |
| Molecular formula | C36H51F6N9O9 |
| CAS | 1334953-96-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 10 mM |
| References | 1. Zhao W , Xu Z , Cao J , et al. Elamipretide (SS-31) Improves Mitochondrial Dysfunction, Synaptic and Memory Impairment Induced by Lipopolysaccharide in Mice[J]. SSRN Electronic Journal, 2019. 2. Anton, Petcherski, Kyle, et al. Elamipretide Promotes Mitophagosome Formation and Prevents its Reduction Induced by Nutrient Excess in INS1 β-Cells.[J]. Journal of Molecular Biology, 2018. |
| Citations | 1. Yang, De-qing, et al. Mitochondrial-Targeting Antioxidant SS-31 Suppresses Airway Inflammation and Oxidative Stress Induced by Cigarette Smoke. Oxidative Medicine and Cellular Longevity. 2021 (2021). |