| Description | DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM. |
| In vitro | DPTIP（30 μM）在星形胶质细胞中减少了50%的外泌体释放。DPTIP（0.03-30 μM）剂量依赖性地阻断EV分泌[1]。 |
| In vivo | In mice, DPTIP potently (10 mg/kg; i.p.) inhibits IL-1β-induced astrocyte-derived EV release. Brain concentrations of DPTIP are above its IC50 for neutral sphingomyelinase 2 inhibition for at least 4 h after the administration of DPTIP[2]. |
| molecular weight | 378.44 |
| Molecular formula | C21H18N2O3S |
| CAS | 351353-48-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 245 mg/mL (647.39 mM), Sonication is recommended. |
| References | 1. Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. 2. Camilo Rojas, et al. DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci Rep. 2018 Dec 7;8(1):17715. |