| Description | DOTAP chloride (1,2-Dioleoyl-3-trimethylammonium-propane chloride) is a useful and effective cationic lipid transfection DNA(plasmids, BacMIDs) and modified nucleic acids (antisense oligonucleotides) without the use of auxiliary lipids. |
| Target activity | Cationic Lipid: |
| Synonyms | (2,3-二油氧基丙基)三甲基氯化铵, 1,2-Dioleoyl-3-trimethylammonium-propane chloride |
| molecular weight | 698.54 |
| Molecular formula | C42H80ClNO4 |
| CAS | 132172-61-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 125 mg/mL (178.94 mM), Sonication is recommended. |
| References | 1. Kim BK, et al. DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes.Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):1996-2001. 2. Xu Y, Xu M, Tong J, et al. Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma[J]. Blood. 2021, 137(11): 1478-1490. |