| Description | DMP-543 (XR-543) is a potassium channel (KV7 channel) blocker that enhances the release of neurotransmitters. |
| In vitro | DMP-543（XR-543）是一种KV7通道阻断剂，同时也能强效增强神经递质的释放。[1][2] 在大鼠脑片中，DMP-543能够增强[3H]ACh的释放（EC50：700 nM）[2]。 |
| Target activity | [3H]-Ach:700 nM(EC50) |
| Synonyms | XR-543 |
| molecular weight | 412.43 |
| Molecular formula | C26H18F2N2O |
| CAS | 160588-45-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (218.2 mM ), Sonication is recommended. |
| References | 1. Ipavec V, et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res. 2011 ; 64(4):397-409. 2. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 ; 285(2):724-730. |