| Description | DMAT (Casein kinase II Inhibitor) is a potent and specific inhibitor of CK2(IC50 value of 130 nM). |
| In vivo | DMAT 阻断细胞生长并诱导癌细胞死亡，无论是在培养中还是在小鼠异种移植模型中[1][2]。 |
| Target activity | DYRK2:0.35 μM , CK2:0.13 μM (IC50, Human CK2) , HIPK3:0.59 μM , DYRK1A:0.41 μM , HIPK2:0.37 μM , Pim1:0.148 μM , PKD1:0.18 μM , Pim3:0.097 μM , CDK2:0.64 μM, Pim2:1.6 μM , β-glucuronidase:1.7 μM |
| Synonyms | Casein kinase II Inhibitor, 2-二甲基氨基-4,5,6,7-四溴苯并咪唑, CK2 Inhibitor |
| molecular weight | 476.79 |
| Molecular formula | C9H7Br4N3 |
| CAS | 749234-11-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (104.87 mM), Sonication is recommended. |
| References | 1. Lawnicka H , Kowalewicz-Kulbat M , Sicinska P , et al. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro[J]. Cell & Tissue Research, 2010, 340(2):371-379. 2. Sass, Gabriele. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT[J]. International Journal of Oncology, 2011, 39(2). |