| Description | Dimiracetam (NT-11624) is an orally active anti-neuropathy compound that inhibits hypersensitivity and neurological alterations and may be used in the study of cognitive disorders, depression and neuropathic pain. |
| In vivo | 雄性 Sprague-Dawley 大鼠腹腔注射（10 毫克/千克的索拉非尼，每天一次，连续 21 天。第14天，大鼠经口急性服用迪米拉西坦（300 mg kg(-1)），单次口服迪米拉西坦可在给药 15 分钟后显著提高疼痛阈值。[1] |
| Synonyms | NT-11624, NT11624, BND11624, ISF4185, BND-11624, ISF-4185 |
| molecular weight | 140.14 |
| Molecular formula | C6H8N2O2 |
| CAS | 126100-97-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Di Cesare Mannelli L, et al. A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam. Neurotoxicology. 2015 Sep;50:101-7. 2. Fariello RG, et al. Broad spectrum and prolonged efficacy of dimiracetam in models of neuropathic pain. Neuropharmacology. 2014 Jun;81:85-94. 3. Farina C, et al.Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain. Bioorg Med Chem. 2008 Mar 15;16(6):3224-32. 4. Torchio L, et al.Determination of the polar drug dimiracetam in human plasma and serum by column-switching high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1995 Apr 7;666(1):169-77. |