Dimethyl DL-Glutamate (hydrochloride) Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	Dimethyl DL-glutamate is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes.
In vitro	Dimethyl DL-Glutamate (hydrochloride) 增强了格列本脲和胰高血糖素样肽1的促胰岛素释放潜力[1]。Dimethyl DL-Glutamate 被用作在研究中穿透细胞的谷氨酸形式，以探究其在β细胞中的作用[2]。
molecular weight	211.64
Molecular formula	C7H14ClNO4
CAS	13515-99-6
Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility	DMSO: 27.5 mg/mL (129.94 mM)
References	1. Jesús Cancelas, María L. Villanueva-Pe?acrrillo, Valverde I , et al. Potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester ofl-glutamic acid in a type 2 diabetes animal model[J]. Endocrine, 2001, 16(2):113-116. 2. Casimir M , Lasorsa F M , Rubi B , et al. Mitochondrial Glutamate Carrier GC1 as a Newly Identified Player in the Control of Glucose-stimulated Insulin Secretion[J]. Journal of Biological Chemistry, 2009, 284(37):25004-25014.

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