| Description | Dimesna (BNP-7787) is a synthetic derivative of dithio-ethane sulfonate with uroprotective properties. |
| In vitro | 在大鼠膀胱癌中,Dimesna可以以剂量依赖方式降低环磷酰胺. |
| In vivo | Dimesna能够调节紫杉醇诱导的MTP超聚合,而Dimesna的体内代谢产物mesna,可防止顺铂诱导的MTP失活。肾有机阴离子转运蛋白OAT1（KM=636 μM）,OAT3（ KM=390 μM ）和OAT4（KM=590 μM）能够特异性的结合Dimesna。 |
| Synonyms | 地美司钠, BNP-7787 |
| molecular weight | 326.34 |
| Molecular formula | C4H8Na2O6S4 |
| CAS | 16208-51-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 13 mg/mL (39.84 mM), Sonication is recommended. |
| References | 1. Parker AR, et al. Mol, Cancer Ther, 2010, 9(9), 2558-2567. 2. Hausheer FH, et al. Cancer Chemother Pharmacol, 2010, 65(5), 941-951. 3. Cutler MJ, et al. J Clin Pharmacol, 2012, 52(4), 530-542. 4. Habs MR, et al. Cancer, 1983, 51(4), 606-609. |
| Citations | 1. Tang Y, Song H, Wang Z, et al. Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations. Cell Reports. 2022, 39(2): 110622 2. Tang Y, Song H, Wang Z, et al.Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations.Cell Reports.2022, 39(2): 110622. |