| Description | Dihydrostreptomycin sulfate (Dihydrostreptomycin sesquisulfate) inhibits protein synthesis by binding to the 30S ribosomal subunit. Dihydrostreptomycin Sulfate is a semi-synthetic aminoglycoside antibiotic with bactericidal properties. This antibiotic is active against most gram-positive and gram-negative organisms and is used in the treatment of tuberculosis and tularemia. |
| In vitro | 抗生素Dihydrostreptomycin 的主要作用机制是与细菌核糖体结合并改变其功能，从而导致蛋白质翻译的减少和异常。它通过与MscL(大通道机械敏感通道)的特定位点结合并改变其构象来进入细菌细胞，因此允许K+和谷氨酸从细胞内流出，同时将Dihydrostreptomycin引入细胞内[1]。 |
| In vivo | Dihydrostreptomycin sulfate 会导致小鼠模型耳蜗损伤，而在Dihydrostreptomycin sulfate 诱发损伤后，螺旋韧带中的细胞可能会发生增殖。这一过程可能与耳蜗功能的恢复有关[2]。 |
| Synonyms | Dihydrostreptomycin sesquisulfate, 双氢链霉索 |
| molecular weight | 730.71 |
| Molecular formula | C21H41N7O12·1·5H2SO4 |
| CAS | 5490-27-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 10 mM DMSO: Insoluble |
| References | 1. Kimitsuki T, et al. Brain Res. 1993, 624(1-2):143-150. 2. Yamashita H, et al. Acta Otolaryngol. 1999, 119(3):322-325. |