| Description | Chlorquinaldol (5,7-Dichloro-8-hydroxy-2-methylquinoline) is a Standardized Chemical Allergen. The physiologic effect of chlorquinaldol is by means of Increased Histamine Release, and Cell-mediated Immunity. |
| In vivo | Chlorquinaldol是hydroxy-8-quinolein的衍生物。Chlorquinaldol在十二指肠-胰腺的分泌物中表现出增强的杀菌活性。在0.1~0.2％（W/V）的Chlorquinaldol浓度下,淋病奈瑟氏球菌和砂眼衣原体在60分钟后减少了大约104。 |
| Synonyms | 5,7-Dichloro-8-hydroxy-2-methylquinoline, Chloquinan, 氯喹那多 |
| molecular weight | 228.07 |
| Molecular formula | C10H7Cl2NO |
| CAS | 72-80-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 6 mg/mL (26.3 mM) DMSO: 50 mg/mL (219.23 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Corrihons I, et al. Pathol Biol (Paris), 1991, 39(2), 136-139. 2. Mett H, et al. Antimicrob Agents Chemother, 1984, 26(1), 35-38. |
| Citations | 1. Chen Y, Chen X, Liang S, et al. Chlorquinaldol inhibits the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 inflammasome and ameliorates imiquimod-induced psoriasis-like dermatitis in mice. Chemico-Biological Interactions. 2022, 365: 110122. |