| Description | Denzimol is a novel anticonvulsant compound.Denzimol is selective for tonic seizures. |
| In vivo | Denzimol（30 mg/kg；p.o.；14天；小鼠）与未处理的小鼠相比，减少了大脑浓度和抗惊厥活性，t1/2 beta 显著从 2.10 变化到 1.53 小时。当大脑中的Denzimol浓度高于15 mcg/g时，完全消除了音调性后肢伸展，而最小有效大脑浓度在急性和反复处理的动物中均为2-3 mcg/g。Denzimol的大脑浓度与其抗惊厥效应在急性和反复处理的动物中密切相关。此外，这些发现似乎表明，反复给药后Denzimol抗惊厥活性的减少，可能是由于药代动力学耐受性的发展。[4] |
| molecular weight | 292.37 |
| Molecular formula | C19H20N2O |
| CAS | 73931-96-1 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 16.67 mg/mL (57.01 mM) |
| References | 1. Graziani G, et al. Denzimol, a new anticonvulsant drug. III. Toxicological evaluation. Arzneimittelforschung. 1983;33(8):1168-1173. 2. Bertin D, et al. Determination of denzimol, a new anticonvulsant agent, and its main metabolite in biological material by gas chromatography and high-performance liquid chromatography. J Chromatogr. 1986;378(1):147-154. 3. Salmona M, et al. Interaction of the anticonvulsants, denzimol and nafimidone, with liver cytochrome P450 in the rat. J Pharm Pharmacol. 1988;40(1):17-21. 4. Abbiati GA, et al. Relationship between the brain levels and the anticonvulsant activity of denzimol after its acute and repeated administration to mice. Pharmacol Res Commun. 1987;19(2):153-161. |