| Description | DCB (3,3'-dichlorobenzaldazine) is an allosteric ligand for mGluR5 and shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB). DCB blocks the positive allosteric regulation of mGluRs with the help of 3,3′-difluorobenzaldazine (DFB). |
| Synonyms | 3,3'-dichlorobenzaldazine |
| molecular weight | 277.15 |
| Molecular formula | C14H10Cl2N2 |
| CAS | 6971-97-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: < 27.71 mg/mL DMSO: 7.14 mg/mL (25.77 mM), Sonication is recommended. |
| References | 1. O'Brien JA, et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol Pharmacol. 2003; 64(3):731-40. |