| Description | Dazostinag disodium (TAK-676) is a novel stimulator of interferon genes (STING) agonist and immune system modulator with antitumor activity that activates dendritic cells, natural killer cells, and T cells. |
| In vitro | 在 THP1-Dual 人类急性髓样白血病细胞和 CT26.WT 细胞中，用 Dazostinag disodium（1.1、3.3、10μM；2小时）进行处理后，结果显示 Dazostinag disodium 呈剂量依赖性地增加了pTBK1、pSTING和 pIRF3 蛋白水平。在没有 STING 表达的情况下，不诱导 pTBK1（S172）或 pIRF3（S396）的磷酸化[1]。 |
| In vivo | 在携带 A20 同种异质瘤 CT26.WT同种异质瘤模型的BALB/c小鼠中，经 Dazostinag disodium（1或2 mg/kg/day；静脉注射；3、6、9、12天）处理后，产生了显著的T细胞依赖性体内抗肿瘤活性，同时激活和增殖了肿瘤微环境内和肿瘤相关淋巴组织中的免疫细胞[1]。 |
| molecular weight | 754.48 |
| Molecular formula | C21H20F2N8Na2O10P2S2 |
| CAS | 2553413-93-5 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Elizabeth CC, et al. TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies. Cancer Research Communications. 2022. 2(6): 489–502. |