| Description | CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM). This compound promotes early fungal apoptosis within the cell cycle, diminishes intracellular concentrations of IL-2, NLRP3, and NF-κBp65 proteins, incites mitochondrial impairment and ROS accumulation, and culminates in fungal cell lysis and death [1]. |
| molecular weight | 468.55 |
| Molecular formula | C27H28N6O2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |