| Description | CYP51/PD-L1-IN-2 (compound L20), a quinazoline with antifungal properties, is a potent dual inhibitor targeting both CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.017 μM). The compound promotes early apoptosis in the fungal cell cycle, markedly diminishes intracellular proteins IL-2, NLRP3, and NF-κBp65, causes mitochondrial damage and ROS build-up, culminating in fungal cell lysis and death [1]. |
| molecular weight | 469.5 |
| Molecular formula | C25H23N7O3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |