| Description | Cyclic-di-GMP is a STING agonist and ubiquitous second messenger, which regulates the formation, motility and virulence of biofilms in various bacterial species. |
| Synonyms | c-di-GMP, cyclic diguanylate, 5GP-5GP |
| molecular weight | 690.41 |
| Molecular formula | C20H24N10O14P2 |
| CAS | 61093-23-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 25 mg/mL (36.21 mM) |
| References | 1. Nakamura T, et al. Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J Control Release. 2015 Oct 28;216:149-57. 2. Burdette DL, et al. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 2011 Sep 25;478(7370):515-8. |