| Description | Cyclamic acid sodium (Cyclohexylsulfamicacidsodium) is a carbonic anhydrase inhibitor and one of the most widely used artificial sweeteners in food and pharmaceuticals.Cyclamic acid sodium shows moderate anticonvulsant activity in a maximal electroshock convulsive seizure model.Cyclamic acid sodium is used in cancer research. |
| In vivo | Cyclamic acid sodium (6000 mg/kg/day; intraperitoneal injection; for 5 days) induced acute DILI mouse model can be established successfully. The toxicity of sodium cyclamate to the liver showed a dose-response and time-response relationship. Cyclamic acid sodium induced liver, heart, and kidney injury are closely related to the inflammatory response mediated by TNF-α and IL-1β.[2] |
| Synonyms | Cyclohexylsulfamicacidsodium, Sodiumcyclamate |
| molecular weight | 201.22 |
| Molecular formula | C6H12NNaO3S |
| CAS | 139-05-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 45.0 mg/mL (223.6 mM), Sonication is recommended. DMSO: 7.5 mg/mL (37.09 mM), Sonication is recommended. |
| References | 1. Leban I, et al. Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates. Acta Crystallogr B. 2007 Jun;63(Pt 3):418-25. 2. Zhou Q, et al. Establishment of a Stable Acute Drug-Induced Liver Injury Mouse Model by Sodium Cyclamate. J Inflamm Res. 2022;15:1599-1615. |