| Description | Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraenoic acid (5-HETE) is 7.8 +/- 1.7 and |
| molecular weight | 310.78 |
| Molecular formula | C18H15ClN2O |
| CAS | 77175-51-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Acetonitrile: 1.55 mg/mL（5.00 mM）, Sonication is recommended. Methanol: 1.55 mg/mL（5.00 mM）, Sonication is recommended. DMSO: 50 mg/mL (160.89 mM), Sonication is recommended. |
| References | 1. Lehmann B, et al. Croconazole: an inhibitor of eicosanoid synthesis in A23187-stimulated human polymorphonuclear leukocytes and human whole blood. Skin Pharmacol. 1995;8(6):326-33. |