| Description | CP21R7 (CP21) is an effective and specific GSK3β inhibitor. It is used as an activator of stem cells prior to the induction of differentiation of stem cells to smooth muscle and endothelial cells. CP21R7 can be combined with BMP4 to commit human pluripotent stem cells to a mesodermal fate. |
| Target activity | PKCα:1900 nM., GSK-3β:1.8 nM |
| Synonyms | CP21 |
| molecular weight | 317.34 |
| Molecular formula | C19H15N3O2 |
| CAS | 125314-13-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 1 mg/mL (3.15 mM) DMSO: 59 mg/mL (185.9 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Gong L, et al. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1693-6. 2. Sahara M, et al. Cell Res. 2015 Jan;25(1):148. 3. Patsch C, et al. Nat Cell Biol. 2015 Aug;17(8):1994-12003. 4. Sahara M, et al. Cell Res. 2014 Jul;24(7):820-41. |