| Description | Columbamine (Columbamin) shows strong activity with IC5 48.1 μM.Columbamine exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity. |
| Synonyms | 非洲防己碱, Columbamin, Dehydroisocorypalmine |
| molecular weight | 338.38 |
| Molecular formula | C20H20NO4 |
| CAS | 3621-36-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3.38 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Bao M , Cao Z , Yu D , et al. Columbamine suppresses the proliferation and neovascularization of metastatic osteosarcoma U2OS cells with low cytotoxicity.[J]. Toxicology Letters, 2012, 215(3):174-180. |
| Citations | 1. Kim Y J, Kim T I, Lee A, et al.Sinomenium acutum Modulates Platelet Aggregation and Thrombus Formation by Regulating the Glycoprotein VI-Mediated Signalosome in Mice.Pharmaceuticals.2023, 17(1): 6. |