| Description | Clorsulon (L631529) is utilized for the treatment of Fasciola hepatica infections in calves and sheep. |
| In vitro | 在羊和小牛中,单次使用Clorsulon（15 mg / kg）能够引起肝片吸虫肝脏的皮层和肠道损伤,从而驱除体内未成熟的肝片吸虫. |
| In vivo | Clorsulon是3-磷酸甘油酸和ATP的竞争性抑制剂（Ki=0.29 mM）,能够抑制葡萄糖利用,乙酸盐和丙酸盐形成。 |
| Target activity | 3-phosphoglycorate:0.29 mM(ki), ATP:0.29 mM(ki) |
| Synonyms | 克洛索隆, L631529, MK401, 氯舒隆 |
| molecular weight | 380.66 |
| Molecular formula | C8H8Cl3N3O4S2 |
| CAS | 60200-06-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 7 mg/mL (18.38 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 71 mg/mL (186.5 mM) |
| References | 1. Mrozik H, et al. J Med Chem, 1977, 20(9), 1225-1227. 2. Schulman MD, et al. Mol Biochem Parasitol, 1982, (3), 133-145. 3. Meaney M, et al. Parasitol Res, 2004, 92(3), 232-241. |