| Description | Clindamycin hydrochloride (Clinimycin HCl) inhibits protein synthesis by acting on the 50S ribosomal. It is the hydrochloride salt form of clindamycin, a semi-synthetic, chlorinated broad-spectrum antibiotic produced by chemical modification of lincomycin. Clindamycin hydrochloride(Clinimycin HCl) is used as a solid in capsules. |
| In vitro | Clindamycin是一种经典的细菌蛋白质合成抑制剂，它通过结合到50S核糖体亚基的23S核糖体RNA上发挥作用。[1] |
| In vivo | Clindamycin hydrochloride 口服给犬类后可快速吸收，平均吸收时间 (MAT) 为 0.87 小时，生物利用度为 72.55%。无论是通过静脉注射 (IV) 还是口服给药，Clindamycin hydrochloride 在犬类体内的总清除率 (CL) 分别为 0.503 和 0.458 L/h/kg。其在稳态时的分布容积 (IV) 为 2.48 L/kg，表明克林默素在体液和组织中分布广泛。Clindamycin hydrochloride 在静脉注射和口服给药后的血清浓度能在大约 10 小时内保持在 0.5 μg/mL 以上。[1] Clindamycin hydrochloride 显著减少犬类口腔异味，自基线水平起至 42 天。同时，它也显著降低了牙齿菌斑、牙石和牙龈出血。[2] 在超声牙石清除、根面平整及抛光 (USRP) 后，Clindamycin hydrochloride (2.5 mg/lb) 显著影响牙周病的牙菌斑和袋深度指标，但对犬类牙龈炎无明显效果。[3] 在 14 至 28 天内治疗，Clindamycin hydrochloride 使犬类浅表性细菌性皮肤炎的完全缓解率达到 71.4% (15/21)。[4] |
| Synonyms | 盐酸克林霉素, Sobelin HCl, Cleocin, Clindamycin HCl, Clinimycin HCl |
| molecular weight | 461.44 |
| Molecular formula | C18H33ClN2O5S·HCl |
| CAS | 21462-39-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 75 mg/mL (162.53 mM), Sonication is recommended. |
| References | 1. Batzias GC, et al. Vet J,2005, 170(3), 339-345. 2. Warrick JM, et al. Vet Ther,2000, 1(1), 5-16. 3. Nielsen D, et al. Vet Ther, 2000, 1(3), 150-158. 4. Bloom PB, et al. J Am Anim Hosp Assoc,2001, 37(6), 537-542. |