| Description | Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is an effective pegylated PROTAC linker, which is often used in PROTAC synthesis of chloroanes (HaloPROTACs). |
| In vitro | PROTACs通过连接器连接两种不同的配体构成；其中一个配体是E3泛素连接酶的配体，另一个则是目标蛋白的配体。PROTACs利用细胞内的泛素-蛋白酶体系统，有选择性地降解目标蛋白[1]。 |
| Synonyms | PROTAC Linker 4 |
| molecular weight | 370.87 |
| Molecular formula | C16H31ClO7 |
| CAS | 1799506-30-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | Ethanol: 90 mg/mL (240 mM), Sonication is recommended. DMSO: 90 mg/mL (240 mM), Sonication is recommended. |
| References | 1. Buckley DL, Raina K, Darricarrere N, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015;10(8):1831-1837. |