| Description | CL 277082 (Ddpmhu) is an acyl coenzyme A:cholesterol O-acyltransferase inhibitor that inhibits granuloma tissue ACAT activity. |
| Synonyms | CL277082, CL-277082, Ddpmhu |
| molecular weight | 430.57 |
| Molecular formula | C26H36F2N2O |
| CAS | 96224-26-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Kelley JL,et al. Influence of the acyl-CoA: cholesterol O-acyltransferase inhibitor, CL 277082, on cholesteryl ester accumulation in rabbit macrophage-rich granulomas and hepatic tissue. Biochim Biophys Acta. 1988 May 2;960(1):83-90. 2. Maechler P,et al. Role of the intestinal acyl-CoA:cholesterol acyltransferase activity in the hyperresponse of diabetic rats to dietary cholesterol. J Lipid Res. 1992 Oct;33(10):1475-84. 3. Maechler P, et al. Importance of exogenous cholesterol in diabetic rats: effects of treatment with insulin or with an acyl-CoA:cholesterol acyltransferase inhibitor. Ann Nutr Metab. 1993;37(4):199-209. 4. Trivedi BK, et al. Inhibitors of acyl-Coa:cholesterol acyltransferase. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents. J Med Chem. 1993 Oct 29;36(22):3300-7. doi: 10.1021/jm00074a011. |