| Description | Cjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin, and it restores p53-dependent transcription and sensitivity to DNA damage |
| In vitro | cjoc42 (0.1、1及10 μM) 单独使用时，并未显示出剂量依赖性的细胞活性变化。cjoc42 (0.5、1及5 μM) 能够抑制gankyrin导致的p53水平在细胞中的下降。[1] |
| Synonyms | cjoc 42, cjoc-42 |
| molecular weight | 415.46 |
| Molecular formula | C20H21N3O5S |
| CAS | 2171519-89-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 65 mg/ml (156.45 mM) |
| References | 1. Chattopadhyay A, et al. Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell. Sci Rep. 2016;6:23732. |