1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one (Cochinchinenin A) is the material basis for the analgesic effect of Dragons Blood.
In vitro	根据中药功效物质基础的操作定义，从实验结果判定了龙血的TTX-R钠电流在DRG神经元中的调控作用物质基础。使用Greco等人的药物相互作用方程评估了从龙血中提取的三种成分的互作效应。研究表明，龙血能够以剂量依赖性的方式抑制TTX-R钠电流的峰值，并影响TTX-R钠电流的激活。Cochinchinenin A、cochinchinenin B和loureirin B的组合效果与龙血的效果高度一致。尽管这三种成分单独使用时可以调节TTX-R钠电流，但相同抑制效率下，单独使用时的浓度分别高于合用时的浓度。这三种成分合用的效应呈现协同作用。
Synonyms	剑叶龙血素A, Cochinchinenin A
molecular weight	286.32
Molecular formula	C17H18O4
CAS	221696-69-1
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility	DMSO: 50 mg/mL (174.63 mM)
References	1. Modulation of dragons blood on tetrodotoxin-resistant sodium currents in dorsal root ganglion neurons and identification of its material basis for efficacy Science in China Series C June 2006, Volume 49, Issue 3, pp 274-285

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