| Description | CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. EC50 value: 2.7 μM for NR2C and 2.8 μM for NR2D. |
| In vitro | CIQ在精神分裂症模型中减少相关行为，并可能在帕金森病模型中增强多巴胺释放。CIQ通过增加含有NR2C或NR2D的受体的通道开放频率两倍（EC50分别为2.7和2.8μM），增强NMDA受体的响应。CIQ对NR2A或NR2B亚型无影响，并且不改变谷氨酸或甘氨酸对通道开放的EC50值。总的来说，CIQ提高了通道开放效率，并增强了NMDA受体反应。 |
| Target activity | NR2C:2.7 μM(EC50), NR2D:2.8 μM(EC50) |
| molecular weight | 467.94 |
| Molecular formula | C26H26ClNO5 |
| CAS | 486427-17-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (106.85 mM) H2O: insoluble |